Abstract
The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes place in an intricate and functionally elegant structure called the renal glomerulus. Normal glomerular function retains circulating cells and valuable macromolecular components of plasma in blood, resulting in urine with just trace amounts of proteins. Endothelial cells of glomerular capillaries, the podocytes wrapped around them, and the fused extracellular matrix these cells form altogether comprise the glomerular filtration barrier, a dynamic and highly selective filter that sieves on the basis of molecular size and electrical charge. Current understanding of the structural organization and the cellular and molecular basis of renal filtration draws from studies of human glomerular diseases and animal models of glomerular dysfunction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-210 |
| Number of pages | 12 |
| Journal | Journal of Cell Biology |
| Volume | 209 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2015 |
ASJC Scopus subject areas
- Cell Biology
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Scott, R. P. (2015). The cell biology of renal filtration. Journal of Cell Biology, 209(2), 199-210. https://doi.org/10.1083/jcb.201410017
Scott, Rizaldy P. ; Quaggin, Susan E. / The cell biology of renal filtration. In: Journal of Cell Biology. 2015 ; Vol. 209, No. 2. pp. 199-210.
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abstract = "The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes place in an intricate and functionally elegant structure called the renal glomerulus. Normal glomerular function retains circulating cells and valuable macromolecular components of plasma in blood, resulting in urine with just trace amounts of proteins. Endothelial cells of glomerular capillaries, the podocytes wrapped around them, and the fused extracellular matrix these cells form altogether comprise the glomerular filtration barrier, a dynamic and highly selective filter that sieves on the basis of molecular size and electrical charge. Current understanding of the structural organization and the cellular and molecular basis of renal filtration draws from studies of human glomerular diseases and animal models of glomerular dysfunction.",
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Scott, RP 2015, 'The cell biology of renal filtration', Journal of Cell Biology, vol. 209, no. 2, pp. 199-210. https://doi.org/10.1083/jcb.201410017
The cell biology of renal filtration. / Scott, Rizaldy P.; Quaggin, Susan E.
In: Journal of Cell Biology, Vol. 209, No. 2, 2015, p. 199-210.
Research output: Contribution to journal › Review article › peer-review
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N2 - The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes place in an intricate and functionally elegant structure called the renal glomerulus. Normal glomerular function retains circulating cells and valuable macromolecular components of plasma in blood, resulting in urine with just trace amounts of proteins. Endothelial cells of glomerular capillaries, the podocytes wrapped around them, and the fused extracellular matrix these cells form altogether comprise the glomerular filtration barrier, a dynamic and highly selective filter that sieves on the basis of molecular size and electrical charge. Current understanding of the structural organization and the cellular and molecular basis of renal filtration draws from studies of human glomerular diseases and animal models of glomerular dysfunction.
AB - The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes place in an intricate and functionally elegant structure called the renal glomerulus. Normal glomerular function retains circulating cells and valuable macromolecular components of plasma in blood, resulting in urine with just trace amounts of proteins. Endothelial cells of glomerular capillaries, the podocytes wrapped around them, and the fused extracellular matrix these cells form altogether comprise the glomerular filtration barrier, a dynamic and highly selective filter that sieves on the basis of molecular size and electrical charge. Current understanding of the structural organization and the cellular and molecular basis of renal filtration draws from studies of human glomerular diseases and animal models of glomerular dysfunction.
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Scott RP, Quaggin SE. The cell biology of renal filtration. Journal of Cell Biology. 2015;209(2):199-210. doi: 10.1083/jcb.201410017
